Paroxetine, also known as Paxil, is a Selective Serotonin-Reuptake Inhibitor (SSRI) used in the treatment of various mood disorders. Mood disorders such as major depressive disorder, OCD, panic disorder, social anxiety disorder, generalized anxiety disorder, PTSD, premenstrual dysphoric disorder, and mild-moderate menopausal vasomotor symptoms. Dosing varies by indication but commonly between 20-50 mg PO qam for immediate release dosage forms and around 12.5-75 mg PO qam for the extended release dosage forms. The absorption of paroxetine is not affected by food and is completely bioavailable after oral administration. The half-life elimination is around 21-24 hours. There is a black box warning for suicidality with the increased risk seen in children, adolescents, and young adults. Always weigh the risks vs benefits when using the medication.



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